Interaction of. gamma. -irradiation with two new antineoplastic agents, aziridinylbenzoquinone (AZQ) and 4'-(acridinylamino)methanesulfon-m-anisidide (AMSA), in murine tumors in vivo

Conference · Sat Sep 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5275211

Johnson, R K; Wodinsky, I; Swiniarski, J; Meaney, K F; Clement, J J

AZQ and AMSA were evaluated in combination with irradiation in murine tumor systems. In mice bearing ascitic P388 leukemia AZQ plus whole-body irradiation was slightly more effective in prolonging lifespan than maximally tolerated doses of either modality alone. Using an assay for cell survival, AZQ did not influence the response of P388 cells to radiation in vivo; the cytotoxicity of the two modalities was simply additive. AMSA, at a therapeutic dose administered prior to irradiation, did alter the response of P388 leukemia to irradiation with both a decrease in shoulder and an increase in slope. AMSA was also evaluated either prior to or after irradiation against B16 melanoma. AMSA alone had no influence on the growth of B16 melanoma. In combination with radiation AMSA pretreatment resulted in somewhat longer tumor growth delay than irradiation alone.

• Research Organization: Arthur D. Little, Inc., Cambridge, MA
• OSTI ID: 5275211
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CESIUM 137
CESIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
GROWTH
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
LOCAL IRRADIATION
MAMMALS
MELANOMAS
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
TUMOR CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES