The effect of 6-aminonicotinamide on the levels of brain amino acids and glucose, and their labeling with 14C after injection of (U-14C) glucose

Journal Article · Thu Oct 01 00:00:00 EDT 1981 · Neurochem. Res.; (United States)

DOI:https://doi.org/10.1007/BF00964420· OSTI ID:5337880

Gaitonde, M K; Lewis, L P; Evans, G; Clapp, A

The brains of rats paralysed at 4 hr after the administration of 6-aminonicotinamide were found to contain decreased levels of glutamate and gamma-aminobutyrate. The glucose content of the brain of the treated rats was several fold higher than in controls. The incorporation of 14C into brain amino acids at 30 min after the injection of (U-14C)glucose was decreased by 16%: this was attributed to mainly decreased labeling of glutamate and associated amino acids. The results are discussed in the light of previous findings that the administration of 6-aminonicotinamide resulted in the blockade of the direct oxidation of glucose by the pentose phosphate pathway.

• Research Organization: Department of Biochemistry, St. George's Hospital Medical School, London
• OSTI ID: 5337880
• Journal Information: Neurochem. Res.; (United States), Journal Name: Neurochem. Res.; (United States) Vol. 6:10; ISSN NERED
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
AMIDES
AMINO ACIDS
ANIMALS
AZINES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTIONS
CHEMISTRY
GLUCOSE
GLUTAMIC ACID
HETEROCYCLIC COMPOUNDS
HEXOSES
INHIBITION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDATION
PYRIDINES
RATS
RODENTS
SACCHARIDES
TRACER TECHNIQUES
VERTEBRATES
VITAMIN B GROUP
VITAMINS