Autoxidation and cytotoxicity

Conference · Mon Dec 31 23:00:00 EST 1979

OSTI ID:5336573

Borg, D C; Schaich, K M; Elmore, Jr, J J

A comprehensive synthesis, or reaction schema, to relate autoxidations of non-lipid compounds to lipid chain peroxidation in vivo is presented. This is done in the context of cytotoxic autoxidation reactions, and it is concluded that hydroxyl radicals produced by iron-dependent Fenton reactions serve as both primary toxicants and as sources of secondary toxicants. The latter stem from lipid chain peroxidation initiated by the Fenton-derived hydroxyl radicals, which are visualized as the obligate coupling step linking enzyme-dependent and non-enzymic autoxidations to potentially toxic outcomes.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5336573
• Report Number(s): BNL-28040; CONF-800591-2
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
550300 -- Cytology
59 BASIC BIOLOGICAL SCIENCES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL REACTIONS
ENZYME ACTIVITY
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXYL RADICALS
LIPIDS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDATION
OXIDOREDUCTASES
PEROXIDASES
PORPHYRINS
RADICALS
REDOX REACTIONS
TOXICITY