Iron and hydroxyl radicals in lipid oxidation: Fenton reactions in lipid and nucleic acids co-oxidized with lipid
Hydroxyl radicals can initiate lipid peroxidation in liquids, but their high reactivity affords reaction paths so short that they are unlikely to reach lipids in membrane bilayers when formed exteriorly. EPR studies of Fenton-like reactions inducing oxidation in bulk lipids indicate that iron-dependent initiation of lipid oxidation in organelles and vesicles may result from hydroxyl radicals formed within the hydrophobic membrane interiors, where they would be inaccessible to typical hydrophilic radical scavengers. The cytotoxic or cytogenetic results of lipid peroxidation, especially in nuclear membranes, may include radiominetic chemical damage to adjacent DNA or nucleoprotein. Preliminary product analyses of nucleic acid basis cooxidized with lipids in vitro support this view.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5233785
- Report Number(s):
- BNL-40923; CONF-8706290-1; ON: DE88007672
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400600 -- Radiation Chemistry
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL REACTIONS
CHROMATOGRAPHY
COMPLEXES
DAMAGE
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
HYDROXYL RADICALS
ION EXCHANGE CHROMATOGRAPHY
IRON COMPLEXES
LIPIDS
MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
OXIDATION
OXYGEN COMPOUNDS
PEROXIDES
RADICALS
RESONANCE
RESPONSE MODIFYING FACTORS
SEPARATION PROCESSES
TRANSITION ELEMENT COMPLEXES