Ultrasonic hyperthermia and radiation in the management of intraocular malignant melanoma

Journal Article · Sun Jun 15 04:00:00 EDT 1986 · Am. J. Ophthalmol.; (United States)

DOI:https://doi.org/10.1016/0002-9394(86)90761-0· OSTI ID:5326881

Coleman, D J; Lizzi, F L; Burgess, S E; Silverman, R H; Smith, M E; Driller, J; Rosado, A; Ellsworth, R M; Haik, B G; Abramson, D H

Hyperthermia and radiation were used in combination to treat four patients with choroidal malignant melanoma. This technique uses ultrasonically induced hyperthermia synergistically with radiation to destroy tumor cells. The lower levels of radiation used should avoid the late vascular and inflammatory complications seen in conventional radiation therapy. Tumors were scanned by a computerized diagnostic ultrasound system before treatment and assigned an acoustic tissue type on the basis of a statistical comparison of their ultrasound backscatter spectrum with spectra of tumors of known pathologic status. During the follow-up period, the longest of which was 15 months, all tumors demonstrated regression patterns consistent with choroidal tumors of the same acoustic tissue types treated with conventional radiation therapy.

• Research Organization: Cornell Univ. Medical College, New York, NY
• OSTI ID: 5326881
• Journal Information: Am. J. Ophthalmol.; (United States), Journal Name: Am. J. Ophthalmol.; (United States) Vol. 6; ISSN AJOPA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
BODY AREAS
BODY TEMPERATURE
DISEASES
DOSES
EYES
FACE
HEAD
HYPERTHERMIA
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION DOSES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SENSE ORGANS
SYNERGISM
TEMPERATURE EFFECTS
THERAPY