Proton beam irradiation and hyperthermia. Effects on experimental choroidal melanoma

Journal Article · Sun Dec 01 04:00:00 EST 1985 · Arch. Ophthalmol. (Chicago); (United States)

DOI:https://doi.org/10.1001/archopht.1985.01050120096028· OSTI ID:5688192

Riedel, K G; Svitra, P P; Seddon, J M; Albert, D M; Gragoudas, E S; Koehler, A M; Coleman, D J; Torpey, J; Lizzi, F L; Driller, J

Ultrasonically induced hyperthermia (4.75 MHz) and proton irradiation (160 meV) were evaluated alone and combined to treat experimental choroidal melanoma in 58 rabbit eyes. Threshold tumoricidal doses were established for each modality. Therapy was performed combining subthreshold doses of heat and radiation. Focused ultrasonic energy via an external beam was found to deliver well-localized heat to an intraocular tumor. Ectopic temperature elevations due to soft-tissue-bone interfaces were alleviated by modifying beam alignment. The results indicate that hyperthermia (43 degrees C for one hour) potentiated the tumoricidal effects of radiation, while sparing normal ocular structures. Therefore, we believe that experimental hyperthermia is suitable as an adjuvant treatment modality. This shows that ultrasound hyperthermia has the potential to increase the efficacy of proton irradiation by lowering radiation doses and thus decreasing posttreatment ocular morbidity in human intraocular malignancies.

• OSTI ID: 5688192
• Journal Information: Arch. Ophthalmol. (Chicago); (United States), Journal Name: Arch. Ophthalmol. (Chicago); (United States) Vol. 12; ISSN AROPA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BEAMS
BIOLOGICAL MODELS
BODY
BODY AREAS
BODY TEMPERATURE
COMBINED THERAPY
DISEASES
DOSES
ELEMENTARY PARTICLES
EXPERIMENTAL NEOPLASMS
EYES
FACE
FERMIONS
HADRONS
HAMSTERS
HEAD
HYPERTHERMIA
MAMMALS
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEON BEAMS
NUCLEONS
ORGANS
PARTICLE BEAMS
PROTON BEAMS
PROTONS
RABBITS
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
RODENTS
SENSE ORGANS
TEMPERATURE EFFECTS
THERAPY
UVEA
VERTEBRATES