Does glucose enhance intestinal calcium absorption by a cellular pathway

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5325553

Carroll, K M; Wood, R J; Rosenberg, I H

Ca absorption is decreased in male SH rats at 5 and 12 wk. The authors studied intestinal Ca transport in 3, 4 and 5 old female SH and WK rats to determine: 1) if the defect is present in female rats, and 2) age of onset of the defect. The authors measured transport using everted duodenal sacs containing /sup 40/Ca (0.4mM) and /sup 45/Ca, suspended in a solution of the same composition and incubated 1 h. Serosal to mucosal concentration (S/M) ratio was lower in SH than WK at all ages studied. Since S/M ratio does not adjust for M to S water movement and weight of transporting tissue, the authors calculated /sup 45/Ca transport. This was lower in SH than WK at 4 and 5 wk, but was the same in both at 3 wk. Serum ionized Ca (mM) in older rats is lower in SH than WK (1.26 +/- 0.02 vs 1.38 +/- 0.03, p < .05) but is the same in both at 3 wk (1.36 +/- 0.04 in both). The authors conclude that in female SH, decreased Ca transport is not present at weaning, nor is serum ionized Ca decreased. These defects develop in parallel with the reported increase in blood pressure.

• Research Organization: Univ. of Chicago, IL
• OSTI ID: 5325553
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ALDEHYDES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL PATHWAYS
BODY
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CARBOHYDRATES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLUCOSE
HEXOSES
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
METABOLISM
METALS
MONOSACCHARIDES
NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
SMALL INTESTINE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES