Nuclear medicine progress report for quarter ending March 31, 1985

Technical Report · Mon Jul 01 04:00:00 EDT 1985

OSTI ID:5323715

Knapp, Jr, F F; Ambrose, K R; Goodman, M M; Srivastava, P C

Radioiodinated 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid (DMIPP) has been prepared as a new terminal iodophenyl-substituted fatty acid containing dimethyl-branching at the beta-position. Iodine-125-labeled DMIPP showed rapid, high myocardial uptake (min, mean % injected dose/g) in fasted rats (5, 4.67; 30, 5.06; 60, 4.79; 120, 4.37), and also exhibited high heart:blood ratios (min, ratio) 5, 3:1; 30, 12:1; 60, 12:1; 120, 13:1. These data demonstrate an unanticipated much longer myocardial residence time with DMIPP (+/sub 1/2/ 7-8 h) than observed with either the 3-monomethyl (BMIPP) analogue (+/sub 1/2/ 30-45 min) or the rapidly metabolized straight-chain (IPP) analogue (+/sub 1/2/ 10-15 min). The (/sup 123/I)DMIPP is thus an excellent candidate for clinical evaluation of regional fatty acid metabolism under conditions where the uptake of energy substrates can be assessed independent of regional blood delivery. Studies with the new activated carbon-based osmium-191/iridium-191m generator system have also continued. A standard lead shipping container has been modified for shipment of the generators to Medical Cooperative investigators. Studies include both left and right ventricular ejection fraction measurements and evaluation of blood flow in the cerebral and leg arteries. Studies with potential new brain imaging agents have also continued and a radioiodinated pargyline analogue has been prepared and evaluated. 18 refs., 6 figs., 3 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5323715
• Report Number(s): ORNL/TM-9609; ON: DE85018077
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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62 RADIOLOGY AND NUCLEAR MEDICINE
AMPHETAMINES
ANALEPTICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL PREPARATION
COMPLEXES
DATA
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISTRIBUTION
DRUGS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
PATIENTS
PLATINUM 195
PLATINUM COMPLEXES
PLATINUM ISOTOPES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
SYMPATHOMIMETICS
SYNTHESIS
TISSUE DISTRIBUTION
TRANSITION ELEMENT COMPLEXES
USES
VEINS
VERTEBRATES