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Nuclear medicine progress report for quarter ending December 31, 1986

Technical Report ·
OSTI ID:6220125
; ; ;

The synthesis of the 4,4'-dimethyl analogue of the model 3,3'-dimethyl fatty acid, 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid (3,3'-DMIPP), is described. The (I-125) labeled 4,4'-DMIPP was evaluated in fasted rats and surprisingly showed higher myocardial uptake and faster blood clearance than the 3,3'-, 6,6'- and 9,9'-DMIPP analogues (heart(heart:blood), % dose/gm, 30 min: 3,3' = 5.06 (12:1), 4,4' = 8.03 (16.7:1), 6,6' = 2.26 (3.1:1), 9,9'= 3.06 (2.77)). Since all analogues have the same chain length, differences in tissue uptake and clearance apparently result from the position of geminal dimethyl-branching. This report describes the development of a ''kit'' for the rapid, one-step radioiodination of N-(p-iodophenyl)maleimide. This work involved the coupling of 4-aminophenylmercuric acetate with maleic anhydride to give the acid amide which was then ring annulated with sodium acetate to give the N-(p-acetylmercuricphenyl)maleimide ''kit.'' The crystalline kit is readily radioiodinated with /*I)I/sub 2/ to give the N-(p-iodophenyl)maleimide protein labeling agent. Shipments of research products were made to medical cooperative programs. 2 refs., 5 figs., 1 tab.

Research Organization:
Oak Ridge National Lab., TN (USA)
DOE Contract Number:
AC05-84OR21400
OSTI ID:
6220125
Report Number(s):
ORNL/TM-10377; ON: DE87011952
Country of Publication:
United States
Language:
English

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
400700 -- Radiochemistry & Nuclear Chemistry
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD CHEMISTRY
BLOOD-PLASMA CLEARANCE
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
CHEMISTRY
CLEARANCE
COPPER 64
COPPER ISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 123
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
PLATINUM 195
PLATINUM ISOTOPES
RADIOCHEMISTRY
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
STABLE ISOTOPES
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
TRACER TECHNIQUES