Ataxia telangiectasia cells exhibit the same radiosensitization response by incorporation of BrdUrd or IdUrd as do normal human cells

Journal Article · Sun Sep 01 00:00:00 EDT 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576768· OSTI ID:5322210

Raaphorst, G P; Azzam, E I; Vadasz, J A

Normal and ataxia telangiectasia (AT) human cells were exposed to 10/sup -5/ mole/liter bromodeoxyuridine (BrdUrd) or iododeoxyuridine (IdUrd). High-pressure liquid chromatography (HPLC) measurements showed that up to 26 and 23% of the thymidine in DNA was substituted by BrdUrd in normal and AT cells. When exposed to equal concentrations of BrdUrd and IdUrd, the BrdUrd caused greater radiosensitization than IdUrd in both normal and AT cells.

• Research Organization: Atomic Energy of Canada Limited Research Co., Pinawa, Manitoba
• OSTI ID: 5322210
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 103:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMETABOLITES
AZINES
BODY
BROMOURACILS
BUDR
CHROMATOGRAPHY
DISEASES
DNA
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IODODEOXYURIDINE
IODOURACILS
LIQUID COLUMN CHROMATOGRAPHY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RIBOSIDES
SEPARATION PROCESSES
SKIN
SKIN DISEASES
TELANGIECTASIS
UPTAKE
URACILS
VASCULAR DISEASES