Sustained postischemic cardiodepression following magnesium-diltiazem cardioplegia

Journal Article · Tue Jul 01 04:00:00 EDT 1986 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-182-42355· OSTI ID:5320491

Wallis, D E; Gierke, L W; Scanlon, P J; Wolfson, P M; Kopp, S J

Magnesium-diltiazem cardioplegia was evaluated in the intact, perfused rat heart to determine whether the joint administration of these agents would adversely affect myocardial contractile and high-energy phosphate recovery following intermittent, normothermic global ischemic arrest. Sequential metabolic and functional analyses were performed on isolated perfused rat hearts during each phase of the experimental protocol: control, normoxic cardioplegia, intermittent global ischemic arrest, and normoxic postischemic control reperfusion. Four different cardioplegic solutions were evaluated: 30 mM KCl, 30 mM KCl with 2 mg diltiazem/liter, 20 mM MgCl/sub 2/, and 20 mM MgCl/sub 2/ with 2 mg diltiazem/liter. Myocardial phosphatic metabolite levels and intracellular pH were analyzed nondestructively in the intact hearts by phosphorus-31 NMR spectroscopy. Corresponding measurements of peak left intraventricular pressure, rate of peak pressure development (dP/dt), and contraction frequency were performed at the midpoint during each 5-min interval of /sup 31/P NMR signal averaging. Magnesium plus diltiazem-treated hearts were distinguished from all other groups by a marked delay in postischemic functional recovery consisting of a prolonged depression in contractility (34% of control, P < 0.01) that persisted throughout the first 50 min of postischemic reperfusion. The apparent adverse interactive effects of excess magnesium and diltiazem suggest that elective ischemic arrest with magnesium cardioplegia in combination with diltiazem may be contraindicated clinically.

• Research Organization: Loyola Univ. Medical Center, Maywood, IL
• OSTI ID: 5320491
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 182:3; ISSN PSEBA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL RECOVERY
BLOOD PRESSURE
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
ELEMENTS
HEART
ISCHEMIA
ISOTOPES
LIGHT NUCLEI
MAGNESIUM
MAGNETIC RESONANCE
MAMMALS
METABOLITES
METALS
MUSCLES
MYOCARDIUM
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
PERFUSED ORGANS
PHOSPHATES
PHOSPHORUS 31
PHOSPHORUS COMPOUNDS
PHOSPHORUS ISOTOPES
RATS
RECOVERY
RESONANCE
RODENTS
SPECTRA
STABLE ISOTOPES
VASCULAR DISEASES
VERTEBRATES