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Effect of sodium fluoride on adrenal gland of rabbit. I. Studies on ascorbic acid and delta 5-3beta hydroxysteroid dehydrogenase activity

Journal Article · · Fluoride; (United States)
OSTI ID:5318200
Rabbits were given 50 mg sodium fluoride/kg body weight through the intragastric route every 24 hours for a total period of 200 days. The left adrenal gland was removed and its total weight recorded. Adrenal glands from rabbits sacrificed at varying intervals for other investigative purposes were also collected and their weights recorded. The data indicate a significant rise in the total weight of the gland. Both ascorbic acid and steroid dehydrogenase (Delta 5-3Beta hydroxysteroid dehydrogenase) were localized in the adrenal gland by histochemical methods. The results indicate that, in rabbits exposed to NaF, a reduction in ascorbic acid content as well as a depletion of steroid dehydrogenase activity occurs especially at the zona glomerulosa. The significance of the increase in weight of the gland to the reduction of the ascorbic acid content and steroid dehydrogenase activity is discussed. 15 references, 4 figures.
Research Organization:
Fluorosis Research Lab., New Delhi, India
OSTI ID:
5318200
Journal Information:
Fluoride; (United States), Journal Name: Fluoride; (United States) Vol. 12:2; ISSN FLUOA
Country of Publication:
United States
Language:
English