Radioprotective copper (II) (3,5-diisopropylsalicylate)/sub 2/ accelerates recovery of immunocompetence

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5317866

Soderberg, L; Barnett, J; Baker, M; Salari, H; Sorenson, J

Copper (II)(3,5-diisopropylsalicate)/sub 2/ (Cu(II) (3,5-dips)2) afforded significant protection when administered subcutaneously 3 hr before whole body irradiation. At 800 Rad (170 Rad/min) using a cesium-137 irradiator, 86% of mice receiving 80 mg/kg of the copper complex survived while only 40% of irradiated mice receiving only the polyvinyl alcohol vehicle survived. Seven days after irradiation femoral bone marrow cells were depleted by 99.5%. This depletion was evident whether or not mice were treated with Cu(II)(3,5-dips)/sub 2/. The ability of bone marrow cells from copper-treated mice to respond to colony-stimulating factors in mouse lung-conditioned medium recovered rapidly reaching 70% of control values 24 days after irradiation, while vehicle-treated, irradiated mice reached only 10% of control activity after 24 days. The antibody responsiveness (anti-sheep erythrocyte plaque-forming cells) of the copper-treated mice recovered rapidly to control values 42 days after irradiation. Vehicle treated controls reached only 34% of control values 42 days after irradiation. Thus, while Cu(II)(3,5-dips)/sub 2/ treatment did not prevent the damaging effects of irradiation, it did accelerate recovery of immunocompetence.

• Research Organization: Univ. of Arkansas for Medical School, Little Rock
• OSTI ID: 5317866
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE MARROW CELLS
CESIUM 137
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
COPPER
DRUGS
ELEMENTS
EXTERNAL IRRADIATION
IRRADIATION
ISOTOPES
LUNGS
MAMMALS
METALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
SURVIVAL TIME
TRANSITION ELEMENTS
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES