Comparative effect of nitroarenes and their parent arenes on hepatic drug and carcinogen metabolism in rats

Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5316452

Asokan, P; Das, M; Bickers, D; Mukhtar, H

The effect of a single topical application of several nitroarenes (1-nitropyrene, nitropyrenes mixture, nitrobenzo(ghi)perylenes mixture, 3-nitrofluoranthene (3-NF), nitrofluoranthenes mixture (NFM), and nitroperylenes mixture (NPM) and their corresponding parent arenes was studied for their effect on hepatic drug and carcinogen metabolism in neonatal rats. All compounds caused highly significant induction of aryl hydrocarbon hydroxylase (AHH), 7-ethoxyresorufin O-deethylase (ERD), 7-ethoxycoumarin O-deethylase activities, and benzo(a)pyrene (BP) metabolism. The induction by each nitroarene was significant when compared to controls or to their corresponding parent non-nitrated arenes. 1-Nitropyrene was least effective in this regard. The inducing effect of NFM and NP was closely similar to 3-methylcholanthrene (3-MC). Benzphentamine N-demethylase, NADPH-cytochrome c reductase, NADH-ferricyanide reductase activities and the levels of cytochrome P-450 and cytochrome b/sub 5/ remained uncharged following treatment with arenes or nitroarenes. However, a shift of approximately 1 nm to the blue region in the absorption of P-450 was observed in nitroarenes-treated animals. A single topical or parenteral administration of 3-NF or NFM to adult rats also resulted in significant induction of ERD and AHH activities and BP metabolism. The parent arene, fluoranthene was ineffective in this regard. The authors studies suggest that nitroarenes are inducers of hepatic monooxygenases and they resemble the 3-MC type of inducers in rats.

• Research Organization: Case Western Research Univ., Cleveland, OH
• OSTI ID: 5316452
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CARCINOGENS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DISPERSIONS
ENZYME ACTIVITY
ENZYMES
GLANDS
HYDROCARBONS
HYDROXYLASES
LIVER
MAMMALS
METABOLISM
MIXTURES
NEONATES
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RODENTS
VERTEBRATES