Gut as source of sepsis after hemorrhagic shock

Journal Article · Mon Feb 01 04:00:00 EST 1988 · Am. J. Surg.; (United States)

DOI:https://doi.org/10.1016/S0002-9610(88)80691-3· OSTI ID:5314489

Sori, A J; Rush, Jr, B F; Lysz, T W; Smith, S; Machiedo, G W

In a model of severe hemorrhagic shock in rats, blood culture findings became positive within 2 to 4 hours of shock. The organisms cultured were primarily gram-negative. To test the hypothesis that the gut was the source of the bacteria, E. coli labeled with carbon-14 oleic acid were fed to rats undergoing hemorrhagic shock. Their plasma was then assayed for carbon-14 activity. Seven of the 14 shocked animals demonstrated increased plasma carbon-14 activity during or after shock. The mortality rate was 100 percent 80 hours postshock, and all animals had E. coli on subsequent blood culture. The seven rats without increased plasma carbon-14 activity had a survival rate of 83 percent postshock. Sham-shocked animals did not exhibit plasma carbon-14 levels greater than the background levels. These data suggest that bacterial translocation occurs during hemorrhagic shock and that the gut is the source of the bacteremia seen during hemorrhagic shock.

• Research Organization: Univ. of Medicine and Dentistry, Newark, NJ (USA)
• OSTI ID: 5314489
• Journal Information: Am. J. Surg.; (United States), Journal Name: Am. J. Surg.; (United States) Vol. 155:2; ISSN AJSUA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BACTERIA
BACTERIAL DISEASES
BIOLOGICAL MODELS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISEASES
ESCHERICHIA COLI
GASTROINTESTINAL TRACT
HYPOTENSION
INFECTIOUS DISEASES
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MICROORGANISMS
MONOCARBOXYLIC ACIDS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
SEPTICEMIA
SURVIVAL CURVES
TRACER TECHNIQUES
VERTEBRATES