Model system that predicts effective half-life for radiolabeled antibody therapy. [Rats]

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90337-2· OSTI ID:5312154

Klein, J L; Ling, M N; Leichner, P K; Kopher, K A; Rostock, R A; Order, S E

Radiolabeled antibodies to tumor associated proteins localize in both experimental and clinical cancers. In the therapeutic applications of radiolabeled antibody, tumor effective half-life along with the concentration of isotope deposited and energies of the isotope used, determine the tumor dose. Antibodies directed against the same antigenic specificity but derived from different species have varied tumor and whole body effective half-lives and as a result, achieve different tumor doses. In vitro testing does not evaluate the in vivo differences in effective half-life that affect tumor dose. The authors have developed an animal model to evaluate the effective half-live and biodistribution of radiolabeled immunoglobulin (IgG) from diverse species. In both the experimental model and in the clinical trials, radiolabeled immunospecific and normal IgG derived from monkey, rabbit, and porcine sources had the longest effective half-lives, goat and sheep had intermediate effective half-lives, and chicken and turkey had the shortest effective half-lives. These species have been immunized for clinical use. The value of this model system is that it appears to be an effective in vivo preclinical screen for tumor effective half-live of antibodies and IgG from diverse species, thus guiding potential clinical use.

• Research Organization: Johns Hopkins Oncology Center, Baltimore, MD
• OSTI ID: 5312154
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BIRDS
CHICKENS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DOMESTIC ANIMALS
DOSES
FOWL
GLOBULINS
GOATS
IMMUNOGLOBULINS
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MONKEYS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RABBITS
RADIATION DOSES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
RUMINANTS
SHEEP
SWINE
THERAPY
TISSUE DISTRIBUTION
VERTEBRATES