Chemical composition of tumorigenic and mutagenic fractions of two coal liquids
The neutral fractions of two coal-derived liquids were separated into their subfractions to identify the chemical components responsible for the tumorigenic and mutagenic activities of these neutral fractions. Using combined gas chromatography/mass spectrometry with both electron impact and chemical ionization techniques, it was determined that the components of the most tumorigenic subfraction included polycyclic aromatic hydrocarbons and neutral nitrogen compounds (pyrolles). On the other hand, the components of the most mutagenic subfractions included polar substituted polycyclic aromatics, such as amines, azaarenes, phenols, and in one oil, aromatic ketones. A detailed account of the compositions of each of the subfractions isolated is given.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5311512
- Report Number(s):
- ORNL/TM-8680; ON: DE84006249
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
016000 -- Coal
Lignite
& Peat-- Health & Safety
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AROMATICS
AZAARENES
AZOLES
BACTERIA
CHEMICAL COMPOSITION
CHROMATOGRAPHY
COAL LIQUIDS
FLUIDS
FRACTIONATION
GAS CHROMATOGRAPHY
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYDROXY COMPOUNDS
KETONES
LIQUIDS
MASS SPECTROSCOPY
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHENOLS
POLYCYCLIC AROMATIC HYDROCARBONS
PYRROLES
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SEPARATION PROCESSES
SPECTROSCOPY
TOXICITY