Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Interstitial pneumonitis following total body irradiation for bone marrow transplantation using two different dose rates

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5311290
; ; ; ;

A total of 22 patients with leukemia have undergone allogeneic bone marrow transplantation (BMT) by the Quebec Co-operative Group for Marrow Transplantation from 1980 to 1982. All patients received 900 cGy total body irradiation (TBI), in a single fraction, on the day preceding BMT. The first 11 patients were treated on a cobalt unit at a constant dose rate of 4.7 to 6.3 cGy/min. Six of these patients developed interstitial pneumonitis (IP). The clinical course of three patients, two with idiopathic and one with drug-induced pneumonitis, was mild and recovery was complete in all. The other three patients developed severe infectious IP and two died. The next 11 patients were treated with a sweeping beam technique on a 4 MV linear accelerator delivering a total tumor dose of 900 cGy at an average dose rate of 6.0 to 6.5 cGy/min but an instantaneous dose rate of 21.0 to 23.5 cGy/min. Eight patients developed severe IP. Five of these were idiopathic and four died. Three were infectious and all died. The fatality of interstitial pneumonitis appeared to be greater in the group treated with the sweeping beam technique.

Research Organization:
Montreal General Hospital, Quebec
OSTI ID:
5311290
Report Number(s):
CONF-8410326-
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:7; ISSN IOBPD
Country of Publication:
United States
Language:
English

Similar Records

Total body irradiation in bone marrow transplantation: the influence of fractionation and delay of marrow infusion
Journal Article · Fri Feb 29 23:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5072233
Interstitial pneumonitis following bone marrow transplantation after low dose rate total body irradiation
Journal Article · Fri Jul 01 00:00:00 EDT 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5747716
Lung damage following bone marrow transplantation. I. The contribution of irradiation. [Rats]
Journal Article · Wed May 01 00:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5436293

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DISEASES
DOSE RATES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
IRRADIATION PROCEDURES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
LINEAR ACCELERATORS
LUNGS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
PNEUMONITIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RESPIRATORY SYSTEM
SIDE EFFECTS
TISSUES
TRANSPLANTS
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES