Lung damage following bone marrow transplantation. I. The contribution of irradiation. [Rats]

Journal Article · Wed May 01 00:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90112-9· OSTI ID:5436293

Cardozo, B L; Zoetelief, H; van Bekkum, D W; Zurcher, C; Hagenbeek, A

High dose whole body irradiation is commonly included in conditioning regimens for bone marrow transplantation for treatment of patients with hematological malignancies. Interstitial pneumonitis is a major complication after BMT. When no infectious cause is found, it is classified as idiopathic IP (IIP). Total body irradiation is often associated with the induction of IIP; however, extrapolation of animal data from the experiments presented indicates that this is not the only factor contributing to IIP in man. Brown Norway (BN/Bi) rats were bilaterally irradiated to the lungs with 300 kV X rays at a high dose rate (HDR; 0.8 Gy/min) and at low dose rate (LDR; 0.05 Gy/min). The LD50 at 180 days was 13.3 Gy for HDR and 22.7 Gy for LDR. The ratios of LD/sub 50/180/ at 0.05 Gy/min to that at 0.8 Gy/min is 1.7, which indicates a great repair capacity of the lungs. Extrapolation of animal data to patient data leads to an estimated dose of about 15-16 Gy at a 50% radiation pneumonitis induction for low dose rate TBI. As the absorbed dose in the lungs of BMT patients rarely exceeds 10 Gy, additional factors might be involved in the high incidence of HP in man after BMT.

• Research Organization: Radiobiological Institute TNO, Rijswijk, Netherlands
• OSTI ID: 5436293
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:5; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DATA
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LETHAL DOSES
LETHAL RADIATION DOSE
LUNGS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
PNEUMONITIS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RATS
RESPIRATORY SYSTEM
RODENTS
SIDE EFFECTS
THERAPY
TISSUES
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION