Total body irradiation in bone marrow transplantation: the influence of fractionation and delay of marrow infusion

Journal Article · Sat Mar 01 00:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90138-8· OSTI ID:5072233

Lichter, A S; Tracy, D; Lam, W C; Order, S E

Bone marrow transplantation (BMT) after total body irradiation (TBI) and cyclophosphamide is being employed increasingly in the therapy of end stage leukemia. Interstitial pneumonitis (IP) represents a major acute toxicity after allogeneic transplantation. A more rapid reconstitution of lymphoid organs and bone marrow post transplant may result in increased immune competence and hence fewer opportunistic pulmonary infections and IP. By delaying the infusion of marrow to 72 hr after TBI (1250 rad at 7.5 rad/min) instead of the customary 24 hr, we can demonstrate an increase in initial repopulation of thymus, spleen and bone marrow, with syngeneic transplants in Lewis rats. Interstitial pneumonitis may also be caused, in part, by the pulmonary toxicity of large single exposures of TBI. Clinical and laboratory data suggest that fractionated TBI may be less toxic to the lung. When fractionated TBI (625 rad x 2, 7.5 rad/min) is compared to single dose TBI (1250 rad, 7.5 rad/min), and increased initial repopulation of lymphoid organs is observed when fractionated therapy is employed. Delay in marrow infusion and fractionation of TBI exposure may have clinical advantages in patients who receive BMT.

• Research Organization: Johns Hopkins Hospital, Baltimore, MD
• OSTI ID: 5072233
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
LEUKEMIA
BIOLOGICAL RADIATION EFFECTS
LUNGS
WHOLE-BODY IRRADIATION
SIDE EFFECTS
BONE MARROW
CELL KILLING
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
PATIENTS
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RADIATION DOSES
RADIOINDUCTION
SPLEEN
SURVIVAL CURVES
THYMUS
TIME DEPENDENCE
TRANSPLANTS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BODY
DATA
DISEASES
DOSES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INFORMATION
IRRADIATION
LYMPHATIC SYSTEM
NEOPLASMS
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RESPIRATORY SYSTEM
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550603 - Medicine- External Radiation in Therapy- (1980-)