Total body irradiation in bone marrow transplantation: the influence of fractionation and delay of marrow infusion

Journal Article · Fri Feb 29 23:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90138-8· OSTI ID:5072233

Lichter, A S; Tracy, D; Lam, W C; Order, S E

Bone marrow transplantation (BMT) after total body irradiation (TBI) and cyclophosphamide is being employed increasingly in the therapy of end stage leukemia. Interstitial pneumonitis (IP) represents a major acute toxicity after allogeneic transplantation. A more rapid reconstitution of lymphoid organs and bone marrow post transplant may result in increased immune competence and hence fewer opportunistic pulmonary infections and IP. By delaying the infusion of marrow to 72 hr after TBI (1250 rad at 7.5 rad/min) instead of the customary 24 hr, we can demonstrate an increase in initial repopulation of thymus, spleen and bone marrow, with syngeneic transplants in Lewis rats. Interstitial pneumonitis may also be caused, in part, by the pulmonary toxicity of large single exposures of TBI. Clinical and laboratory data suggest that fractionated TBI may be less toxic to the lung. When fractionated TBI (625 rad x 2, 7.5 rad/min) is compared to single dose TBI (1250 rad, 7.5 rad/min), and increased initial repopulation of lymphoid organs is observed when fractionated therapy is employed. Delay in marrow infusion and fractionation of TBI exposure may have clinical advantages in patients who receive BMT.

• Research Organization: Johns Hopkins Hospital, Baltimore, MD
• OSTI ID: 5072233
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CELL KILLING
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INFORMATION
IRRADIATION
LEUKEMIA
LUNGS
LYMPHATIC SYSTEM
NEOPLASMS
NUMERICAL DATA
ORGANS
PATIENTS
PNEUMONITIS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RESPIRATORY SYSTEM
SIDE EFFECTS
SPLEEN
SURVIVAL CURVES
THYMUS
TIME DEPENDENCE
TISSUES
TRANSPLANTS
WHOLE-BODY IRRADIATION