Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.13.5039· OSTI ID:5299676

Finger, L R; Kagan, J; Christopher, G; Kurtzberg, J; Hershfield, M S; Nowell, P C; Croce, C M ^[1]

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1. Temple Univ. School of Medicine, Philadelphia, PA (USA)

The authors analyzed a t(1;14)(p32;q11) chromosomal translocation in a human lymphohemopoietic stem cell line derived from a patient with acute T-lymphoblastic leukemia. The chromosomal joining on the 1p+ chromosome occurred at the T-cell receptor {delta} diversity (D{delta}{sub 2}) segment, and the reciprocal chromosomal joining on the 14q-chromosome occurred at the T-cell {delta} diversity segment D{delta}{sub 1}. The involvement of {delta} diversity segments at the translocation junction suggests that the translocation occurred during an attempt at D{delta}{sub 1}-D{delta}{sub 2} joining in a stem cell. The segment of chromosome 1 at band p32, adjacent to the chromosomal breakpoint, encodes a transcriptional unit designated TCL5 (T-cell leukemia/lymphoma 5). The differential expression of the TCL5 RNA transcripts in this lymphohemopoietic stem cell line relative to several other T- and B-cell lines suggests that TCL5 gene expression is an integral event in the pathogenesis of the T-cell leukemia. Rearrangement of the TCL5 locus in a human melanoma cell line carrying a del(1p32) further implies that the TCL5 gene may play a role in malignant transformation.

• OSTI ID: 5299676
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:13; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CARCINOGENESIS
ETIOLOGY
ONCOGENES
GENE REGULATION
TUMOR CELLS
CHROMOSOMAL ABERRATIONS
DNA SEQUENCING
HETEROCHROMOSOMES
LEUKEMIA
LYMPHOCYTES
MELANOMAS
PATIENTS
PHOSPHORUS 32
STEM CELLS
TRANSCRIPTION
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
GENES
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
ISOTOPES
LEUKOCYTES
LIGHT NUCLEI
MATERIALS
MUTATIONS
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
PATHOGENESIS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
550401* - Genetics- Tracer Techniques