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Genetic analysis of gamma-ray mutagenesis in yeast. I. Reversion in radiation-sensitive strains

Journal Article · · Genetics; (United States)
OSTI ID:5298955
;
The frequency of revertants induced by /sup 60/Co ..gamma.. rays of the ochre allele, cyc1-9, has been measured in radiation-sensitive strains carrying one of 19 nonallelic mutations and in wild-type strains. The results indicate that ionizing radiation mutagenesis depends on the activity of the RAD6 group of genes and that the gene functions employed are very similar, but probably not identical, to those that mediate uv mutagenesis. Repair activities dependent on the functions of the RAD50 through RAD57 loci, the major pathway for the repair of damage caused by ionizing radiation, do not appear to play any part in mutagenesis. A comparison between the ..gamma..-ray data and those obtained previously with uv and chemical mutagens suggests that the RAD6 mutagenic pathway is in fact composed of a set of processes, some of which are concerned with error-prone, and some with error-free, recovery activities.
Research Organization:
Univ. of Rochester, NY
OSTI ID:
5298955
Journal Information:
Genetics; (United States), Journal Name: Genetics; (United States) Vol. 93:2; ISSN GENTA
Country of Publication:
United States
Language:
English

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Related Subjects

550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DYNAMIC FUNCTION STUDIES
ELECTROMAGNETIC RADIATION
FUNGI
GAMMA RADIATION
GENE MUTATIONS
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
MUTAGENESIS
MUTANTS
MUTATIONS
NUCLEI
ODD-ODD NUCLEI
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY
RECOVERY
REPAIR
REVERTANTS
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
ULTRAVIOLET RADIATION
YEARS LIVING RADIOISOTOPES
YEASTS