Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants
Journal Article
·
· J. Bacteriol.; (United States)
OSTI ID:5289373
Dominant mutations at two newly identified loci, designated SRS1 and SRS2, that metabolically suppress the trimethoprim sensitivity of rad6 and rad18 strains, have been isolated from trimethorprim-resistant mutants arising spontaneously in rad6-1 rad18-2 strains of the yeast Saccharomyces cerevisiae. The SRS2 mutations also efficiently suppress the ultraviolet light sensitivity of the parent strains. They do not, however, suppress their sensitivity to ionizing radiation or their deficiency with respect to induced mutagenesis and sporulation. Such observations support the hypothesis that RAD6-dependent activities can be separated into two functionally distinct groups: a group of error-free repair activities that are responsible for a large amount of the radiation resistance of wild-type strains and also for their resistance to trimethoprim, and a group of error-prone activities that are responsible for induced mutagenesis and are also important in sporulation, but which account at best for only a very small amount of wild-type recovery.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 5289373
- Journal Information:
- J. Bacteriol.; (United States), Journal Name: J. Bacteriol.; (United States) Vol. 139:3; ISSN JOBAA
- Country of Publication:
- United States
- Language:
- English
Similar Records
The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway
RAD6/sup +/ gene of Saccharomyces cerevisiae codes for two mutationally separable deoxyribonucleic acid repair functions
Studies of DNA repair in saccharomyces cerevisiae. I. Characterization of a new allele of RAD6. II. Investigation of events in the first cell cycle after DNA damage
Journal Article
·
Sat Mar 31 23:00:00 EST 1990
· Genetics; (USA)
·
OSTI ID:6790649
RAD6/sup +/ gene of Saccharomyces cerevisiae codes for two mutationally separable deoxyribonucleic acid repair functions
Journal Article
·
Sat Jan 31 23:00:00 EST 1981
· Mol. Cell. Biol.; (United States)
·
OSTI ID:5810071
Studies of DNA repair in saccharomyces cerevisiae. I. Characterization of a new allele of RAD6. II. Investigation of events in the first cell cycle after DNA damage
Thesis/Dissertation
·
Sun Dec 31 23:00:00 EST 1978
·
OSTI ID:5525697
Related Subjects
550400 -- Genetics
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL PATHWAYS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
ELECTROMAGNETIC RADIATION
FUNGI
GENETIC CONTROL
INHIBITION
IONIZING RADIATIONS
MICROORGANISMS
MUTAGENESIS
MUTANTS
PEST CONTROL
PLANTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SPORES
ULTRAVIOLET RADIATION
YEASTS
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL PATHWAYS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
ELECTROMAGNETIC RADIATION
FUNGI
GENETIC CONTROL
INHIBITION
IONIZING RADIATIONS
MICROORGANISMS
MUTAGENESIS
MUTANTS
PEST CONTROL
PLANTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SPORES
ULTRAVIOLET RADIATION
YEASTS