Application of robotics to radiopharmaceutical preparation: controlled synthesis of fluorine-18 16 alpha-fluoroestradiol-17 beta
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5278451
A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting radiopharmaceutical, 16 alpha-(18F) fluoroestradiol-17 beta. This radiopharmaceutical is prepared in a three-step synthesis (preparation of (18F)-tetrabutylammonium fluoride, SN2 displacement of a triflate, and ketone reduction) and is purified by high performance liquid chromatography (HPLC). All steps in the synthesis and HPLC purification are controlled by the robot system with no manual intervention. This represents a new approach to the complete automation of radiopharmaceutical production.
- Research Organization:
- Mallinckrodt Institute of Radiology, St. Louis, MO
- OSTI ID:
- 5278451
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
AUTOMATION
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
DRUGS
ESTRADIOL
ESTRANES
ESTROGENS
FLUORINE 18
FLUORINE ISOTOPES
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PURIFICATION
RADIOISOTOPES
RADIOPHARMACEUTICALS
ROBOTS
STEROID HORMONES
STEROIDS
SYNTHESIS
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
AUTOMATION
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
DRUGS
ESTRADIOL
ESTRANES
ESTROGENS
FLUORINE 18
FLUORINE ISOTOPES
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PURIFICATION
RADIOISOTOPES
RADIOPHARMACEUTICALS
ROBOTS
STEROID HORMONES
STEROIDS
SYNTHESIS