Therapeutic potentiation of combined cis-dichlorodiammineplatinum (II) and irradiation by ICRF-159

Conference · Wed Aug 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5275480

Kovacs, C J; Schenken, L L; Burholt, D R

The effect of fractionated ICRF-159 (25 mg/kg, q3hx4) pretreatment on the antitumor activity of cis DDP + irradiation combinations has been evaluated using the Lewis lung tumor. All three agents given alone as single treatments result in transient interruption of proliferative activity with only slight to moderate alterations of tumor growth. Fractionated ICRF-159 treatment, while eliciting low cytotoxicity, results in a partial cytokinetic redistribution of tumor cells enhancing subsequent radiotherapy and chemotherapy with cis DDP. For cis DDP-radiation combinations, where cis DDP precedes irradiation, increasing the intertreatment time from 6 h to 24 h results in synergistic interactions and increased treatment efficacy. When cis DDP-radiation combinations followed fractionated ICRF-159, regression was greatly enhanced suggesting that relatively non-cytotoxic agents may be used to sensitize low growth fraction, resistant tumors to subsequent combined-mode therapy.

• Research Organization: Allegheny General Hospital, Pittsburgh, PA
• OSTI ID: 5275480
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL PROLIFERATION
COMPLEXES
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GROWTH
HYDROGEN ISOTOPES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LUNGS
MAMMALS
MICE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
PLATINUM COMPLEXES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SYNERGISM
TIME DEPENDENCE
TRACER TECHNIQUES
TRANSITION ELEMENT COMPLEXES
TRITIUM
TUMOR CELLS
VERTEBRATES
VOLUME
X RADIATION
YEARS LIVING RADIOISOTOPES