Comparison of iodine-131 OIH and technetium-99m MAG3 renal imaging in volunteers

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · J. Nucl. Med.; (United States)

OSTI ID:5271036

Taylor, A Jr; Eshima, D; Fritzberg, A R; Christian, P E; Kasina, S

Animal studies have suggested that the nonisomeric N3S triamide mercaptide ligand, /sup 99m/Tc mercaptoacetyltriglycine (MAG3), may provide a satisfactory /sup 99m/Tc-labeled replacement for /sup 131/I hippurate (OIH). Sequential 30-min (/sup 99m/Tc)MAG3 (5-10 mCi) and (/sup 131/I)OIH (300 microCi) imaging studies were performed in ten normal volunteers in order to compare the image quality, renal excretion, blood clearance, and time to peak height of the renogram curve. In addition, (/sup 99m/Tc) MAG3 (5 mCi) and (/sup 131/I)OIH (150 microCi) were administered simultaneously in eight volunteers for comparison of 180-min blood and plasma clearances and urine excretion. In the sequential imaging studies, the blood clearance of (/sup 99m/Tc)MAG3 was more rapid than (/sup 131/I)OIH with a mean clearance of 1.30 l/min compared with 0.88 l/min for (/sup 131/I)OIH (p less than 0.05). Seventy-three percent of the injected dose of the MAG3 was excreted by 30 min compared with 66.8% for (/sup 131/I)OIH. Whole kidney and cortical renogram curves showed no significant difference in the time to peak height for MAG3 and (/sup 131/I)OIH. In all subjects, the quality of the (/sup 99m/Tc)MAG3 images were clearly superior to (/sup 131/I)OIH. Following simultaneous injection, blood and plasma clearances for (/sup 131/I)OIH were more rapid than MAG3 when determined for multiple time intervals from 0-30 to 0-180 min (p less than or equal to 0.05). The 0-30-min clearances of MAG3 and (/sup 131/I)OIH were only slightly greater than the 0-180-min clearances and can be used to obtain valid comparisons of the two agents. As in the sequential study, 30-min urine excretion was greater for MAG3 than (/sup 131/I)OIH (73.1 compared with 69.6%) but the difference was not statistically significant.

• Research Organization: Univ. of Utah School of Medicine, Salt Lake City
• OSTI ID: 5271036
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
COMPARATIVE EVALUATIONS
COMPUTERS
COUNTING TECHNIQUES
CREATININE
DAYS LIVING RADIOISOTOPES
DRUGS
EXCRETION
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
IMAGES
IMIDAZOLES
IMINES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RENAL CLEARANCE
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES