Evaluation of Tc-99m mercaptoacetyltriglycine as a potential replacement for I-131 Hippurate in human subjects

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5975148

Taylor, A Jr; Eshima, A; Fritzberg, A R; Christian, P E; Kasina, S; Milton, W; Datz, F L

Animal studies suggest that the N/sub 3/S ligand, Tc-99m mercaptoacetyltriglycine (MAG/sub 3/) may provide a satisfactory Tc-99m replacement for I-131 hippurate (OIH). The ligand avoids the problem of stereo isomers and can be prepared in kit form. Tc-99m MAG/sub 3/ (10 mCi) and OIH (300 ..mu..Ci) studies were performed in 10 normal volunteers and 8 patients to compare the image quality, renal excretion, blood clearance, and time to peak height of the renogram curve. Serum creatinines in the 8 patients ranged from 1.6-9.8 mg/dl. Blood clearance data were obtained in 7 volunteers and 5 patients. Tc-99m MAG/sub 3/ was cleared more rapidly than OIH with a mean clearance of 1.30 L/min compared to .88 L/min for OIH. In the patients, MAG/sub 3/ had a mean clearance of .44 L/min versus .43 L/min for OIH. Thirty minute urine collections obtained from 3 of 8 patients showed no difference in the excretion of MAG/sub 3/ and OIH. There was no significant difference in the time to peak height for MAG/sub 3/ and OIH in either the volunteers or patients. In all subjects, the quality of the Tc-99m MAG/sub 3/ images was clearly superior to OIH. In summary, preliminary results suggest that Tc-99m MAG/sub 3/ may be a potential replacement for OIH and further clinical evaluation is warranted.

• Research Organization: Univ. of Utah School of Medicine, Salt Lake City, UT
• OSTI ID: 5975148
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISTRIBUTION
DRUGS
DYNAMIC FUNCTION STUDIES
EVALUATION
EXCRETION
FUNCTIONS
GLYCYLGLYCINE
HIPPURIC ACID
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LABELLING
LIGANDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RENAL CLEARANCE
RETENTION FUNCTIONS
SCINTISCANNING
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THIOLS
TISSUE DISTRIBUTION
UPTAKE
USES
YEARS LIVING RADIOISOTOPES