Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Clinical comparison of I-131 orthoiodohippurate and the kit formulation of Tc-99m mercaptoacetyltriglycine

Journal Article · · Radiology; (United States)
; ; ; ; ;

Previous studies in animals and humans have shown that technetium-99m mercaptoacetyltriglycine (MAG3) purified by high-performance liquid chromatography is a renal tubular agent with characteristics similar to those of iodine-131 orthoiodohippurate (OIH). A kit formulation for Tc-99m MAG3 has been developed and compared with I-131 OIH in 17 patients with suspected renal dysfunction and three potential kidney donors. There were no adverse reactions. Tc-99m MAG3 images were of good quality and consistently better than I-131 OIH images. There was no significant difference in the relative renal uptake of Tc-99m MAG3 and I-131 OIH. The 30-minute urinary excretion of Tc-99m MAG3 was 36.4%, versus 40.4% for I-131 OIH. The average plasma clearance of Tc-99m MAG3 (138 mL/min +/- 117) was less than that of I-131 OIH (272 mL/min +/- 205) (P less than .001); however, there was good correlation between the Tc-99m MAG3 and I-131 OIH clearances (r = .87). The volume of distribution of Tc-99m MAG3 (5.96 L +/- 1.94) was less than that of I-131 OIH (9.41 L +/- 3.73) (P less than .001). These characteristics and the advantages of a simple kit formulation should lead to widespread clinical use.

Research Organization:
Emory Univ. School of Medicine, Atlanta, GA (USA)
OSTI ID:
6350891
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 170; ISSN RADLA
Country of Publication:
United States
Language:
English

Similar Records

The kidney: Imaging with Tc-99m mercaptoacetyltriglycine, a technetium-labeled analog of iodohippurate
Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Radiology; (United States) · OSTI ID:5820313
Evaluation of Tc-99m mercaptoacetyltriglycine in patients with impaired renal function
Journal Article · Sat Jan 31 23:00:00 EST 1987 · Radiology; (United States) · OSTI ID:6934805
Comparison of iodine-131 OIH and technetium-99m MAG3 renal imaging in volunteers
Journal Article · Sun Jun 01 00:00:00 EDT 1986 · J. Nucl. Med.; (United States) · OSTI ID:5271036

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
CHROMATOGRAPHY
CLEARANCE
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
TECHNETIUM 99
TECHNETIUM ISOTOPES
UPTAKE
UROGENITAL SYSTEM DISEASES
YEARS LIVING RADIOISOTOPES