Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Evaluation in dogs and humans of three potential technetium-99m myocardial perfusion agents

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5270734
; ; ; ; ; ; ; ; ;

The biodistribution of the three cationic /sup 99m/Tc complexes (/sup 99m/Tc(TMP)6)+, (/sup 99m/Tc(POM-POM)3)+, and (/sup 99m/Tc(TBIN)6)+--where TMP represents trimethylphosphite, POM-POM represents 1,2-bis(dimethyoxyphosphino)ethane, and TBIN represents t-butylisonitrile--have been evaluated in humans and dogs. Each agent was studied in three normal volunteers at rest, while (/sup 99m/Tc(POM-POM)3)+ and (/sup 99m/Tc(TBIN)6)+ were each studied in one normal volunteer at exercise. Even though all three agents yield good myocardial images in dogs, none appear suitable for clinical use as myocardial perfusion imaging radiopharmaceuticals. In humans, (/sup 99m/Tc(TMP)6)+ and (/sup 99m/Tc(POM-POM)3)+ clear very slowly from the blood and provide myocardial images only several hours after injection. (/sup 99m/Tc(TBIN)6)+ clears rapidly from the blood, but accumulation in the lung obscures the myocardial image for the first hour after injection; at later times, activity in the liver and spleen masks the apical wall. These results correlate with the blood-binding properties of the three complexes. (/sup 99m/Tc(TMP)6)+ and (/sup 99m/Tc(POM-POM)3)+ bind tightly to the plasma of human blood, but not to the plasma of dog blood; (/sup 99m/Tc(TBIN)6)+ does not bind tightly to the plasma of either dog or human blood. Among the Tc(I) complexes studied to date in humans, (/sup 99m/Tc(TBIN)6)+ appears to be unique in biodistribution pattern, blood-binding properties, and the fact that exercise improves the ultimate myocardial image. All the Tc(I) complexes appear to undergo myocardial accumulation by a mechanism different from that utilized by Tc(III) complexes. Animal studies alone are not adequate to evaluate the potential utility of /sup 99m/Tc cationic complexes for myocardial perfusion studies.

Research Organization:
Univ. of Milan, Italy
OSTI ID:
5270734
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 3; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

Pharmacological characterization of Tc-99m(CN-t-butyl)/sub 6//sup +/: A potential heart agent
Conference · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States) · OSTI ID:6574915
Synthesis, characterization and identification of the hexakis (trimethylphosphite) (Tc-99m)technetium(I) cation as a myocardial imaging agent
Conference · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States) · OSTI ID:6861670
Human biodistribution, dosimetry and clinical use of technetium(III)-99m-Q12
Journal Article · Sat Oct 01 00:00:00 EDT 1994 · Journal of Nuclear Medicine · OSTI ID:458858

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
CLEARANCE
COMPARATIVE EVALUATIONS
CONTROL
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
DRUGS
ERYTHROCYTES
EXERCISE
GLANDS
HEART
HOURS LIVING RADIOISOTOPES
IMAGES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MAN
MATERIALS
MUSCLES
MYOCARDIUM
NITRILES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
QUALITY CONTROL
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES