Pharmacological characterization of Tc-99m(CN-t-butyl)/sub 6//sup +/: A potential heart agent
The authors have investigated the pharmacological behavior of hexakis (t-butylisonitrile)Tc(I) and evaluated it as a potential myocardial perfusion radiopharmaceutical. This complex produces good to excellent heart images in rats, guinea pigs, rabbits, cats, dogs, pigs and baboons. Good heart uptake in guinea pigs, cats and pigs may be predictive of good myocardial imaging in man, since the hearts of these three species extract Tl-201, but not Tc-99m(dmpe)/sub 2/-Cl/sub 2//sup +/ (similar to man, but unlike other animal species). Biodistribution studies reveal initial heart uptake of 1.3 to 2.2% of the injected activity. Imaging and biodistribution show significant initial lung activity which clears substantially during the first hour after injection. Little or no myocardial washout is observed. In rabbits with ischemia induced by coronary artery ligation, the complex distributes as a function of blood flow. Simultaneous injection of Tl-201 and Tc-99m (CN-t-butyl)/sub 6//sup +/ with subsequent dual isotope imaging shows that their initial distribution is a similar. The complex is extracted 100% by isolated rabbit and guinea pig hearts perfused with buffer. When human blood is mixed and co-injected with the complex, myocardial extraction is reduced, but remains high (73-75%). Uptake of the complex by rat myocytes in culture is not inhibited by either ouabain or K/sup +/. These results suggest that this complex may be a promising myocardial perfusion agent and should be tested in man.
- Research Organization:
- New England Nuclear Corp., Billerica, MA
- OSTI ID:
- 6574915
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
COMPLEXES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
EVALUATION
FUNCTIONS
HEART
HOURS LIVING RADIOISOTOPES
IMAGES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
REACTION KINETICS
RETENTION FUNCTIONS
SCINTISCANNING
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
UPTAKE
YEARS LIVING RADIOISOTOPES