Basal kinetic studies of Tc-99m DMPE as a myocardial imaging agent in the dog
Newly synthesized /sup 99m/Tc dichlorobis(1,2-dimethylphosphino)ethane (DMPE) was investigated as a myocardial imaging agent with respect to its kinetics (dependent on both time and regional coronary blood flow), its percent organ uptake, and its imaging characteristics in the anesthetized dog. Most of these data are compared with those of /sup 201/Tl. Blood clearance of the two agents is essentially the same. Compared with /sup 201/Tl, /sup 99m/Tc DMPE shows faster overall kinetics, higher heart-to-lung ratio, equally good correlation with a wide range of regional blood flows, and higher liver uptake. At the time of peak myocardial uptake, the mean heart uptake of /sup 201/Tl is 4.3%, compared with 2.9% for /sup 99m/Tc DMPE, yet only 0.9% uptake of /sup 99m/Tc DMPE is found in the lung as compared with 3.3% for /sup 201/Tl. These differences result in a heart-to-lung ratio of 2:1 for /sup 99m/Tc DMPE and 1:1 for /sup 201/Tl, based on the data obtained from the time-activity curve. The quantitative findings are supported by the superior quality of /sup 99m/Tc DMPE images of both normal and infarcted dog heart. The high hepatic uptake of /sup 99m/Tc DMPE is not a serious problem if images are obtained within 5-60 min after dose. These basic kinetic studies suggest that /sup 99m/Tc DMPE is a promising myocardial imaging agent.
- Research Organization:
- University of Cincinnati, Ohio
- OSTI ID:
- 6377683
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:12; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pathophysiology of technetium-99m stannous pyrophosphate and thallium-201 scintigraphy of acute anterior myocardial infarcts in dogs
Synthesis, characterization and identification of the hexakis (trimethylphosphite) (Tc-99m)technetium(I) cation as a myocardial imaging agent
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PERFORMANCE TESTING
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TESTING
THALLIUM 201
THALLIUM ISOTOPES
TISSUE DISTRIBUTION
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES