Human biodistribution, dosimetry and clinical use of technetium(III)-99m-Q12
- Univ. of Milano, Saluggia (Italy); and others
Technetium(III)-99m-Q12, trans-(1,2-bis(dihydro-2,2,5,5-tetramethyl - 3(2H)furanone - 4 -methyleneimino)ethane)bis(tris(3 -methoxy-1-propyl)-phosphine)technetium(III)-99m, is a nonreducible complex of Tc(III) which is herein evaluated as a myocardial perfusion imaging agent. The biodistribution and dosimetry of {sup 99m}Tc-Q12 were assessed in 10 normal volunteers, while its potential clinical use was evaluated in 70 patients. Safety parameters measure up to 24 hr postinjection demonstrate no clinically significant drug-related adverse reactions. Technetium(III)-99m-Q12 exhibits good heart uptake (2.2% injected dose at 1 hr postinjection; under resting conditions) and no detectable myocardial washout or redistribution up to 5 hr postinjection. The biodistribution is characterized by very rapid hepatobiliary clearance which allows effective myocardial imaging at times as short as 15 min postinjection. Blood and plasma clearances and myocardial uptake are rapid, while lung uptake is minimal. The heart-to-lung and heart-to-liver ratios are higher at stress than at rest, independent of the time elapsed between injection and image acquisition, and independent of whether the patient is fasted or fed after tracer administration. A preliminary correlation shows that 46/47 patients with angio-graphically demonstrated CAD also have perfusion defects demonstrated by {sup 99m}Tc-Q12. On the basis of the studies reported herein, {sup 99m}Tc-Q12 appears to be a promising myocardial perfusion imaging agent. 31 refs., 6 figs., 3 tabs.
- OSTI ID:
- 458858
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: 10 Vol. 35; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
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