Technetium-99m hexakis 2-methoxyisobutyl isonitrile: Human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging

Journal Article · Wed Mar 01 04:00:00 EST 1989 · J. Nucl. Med.; (United States)

OSTI ID:5820290

Wackers, F J; Berman, D S; Maddahi, J; Watson, D D; Beller, G A; Strauss, H W; Boucher, C A; Picard, M; Holman, B L; Fridrich, R

The biodistribution, dosimetry, and safety of a new myocardial imaging agent, /sup 99m/Tc-hexakis-2-methoxyisobutyl isonitrile (HEXAMIBI), was evaluated in 17 normal volunteers at rest and exercise (Phase I studies). Technetium-99m HEXAMIBI clears rapidly from the blood with good myocardial uptake and favorable myocardial-to-background ratios for myocardial imaging. Dosimetry allows for administration of up to 30 mCi (1, 110 Bq) of (/sup 99m/Tc)HEXAMIBI. The myocardial images were of good quality and appeared less granular with sharper myocardial walls compared to /sup 201/T1 images. The clinical efficacy of (/sup 99m/Tc)HEXAMIBI planar stress and rest imaging was evaluated in a multicenter Phase II clinical trial involving 38 patients. Of 36 patients with significant coronary artery disease, 35 patients (97%) had abnormal /sup 201/T1 stress images, and 32 (89%) had abnormal (/sup 99m/Tc)HEXAMIBI stress images (P = N.S.). Technetium-99m HEXAMIBI images correlated in 31/35 patients (86%) who had either scar or ischemia on /sup 201/T1 images. By segmental myocardial analysis, exact concordance was obtained in 463/570 myocardial segments (81%). This multicenter Phase I and II study indicates that planar (/sup 99m/Tc)HEXAMIBI stress imaging is safe and compares well with /sup 201/T1 stress imaging for detection of coronary artery disease.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT (USA)
• OSTI ID: 5820290
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
CARDIOVASCULAR DISEASES
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISTRIBUTION
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EXERCISE
HEAVY NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
PATIENTS
RADIATION DOSES
RADIOISOTOPES
RADIOPHARMACEUTICALS
SAFETY
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TISSUE DISTRIBUTION