Total lymphoid irradiation in refractory systemic lupus erythematosus
In two patients with systemic lupus erythematosus, conventional therapy was considered to have failed because of persistent disease activity and unacceptable side effects. Both were treated with total lymphoid irradiation without clinical benefit, despite adequate immunosuppression as documented by markedly reduced numbers of circulating T lymphocytes and T-lymphocyte-dependent proliferative responses in vitro. The first patient developed herpes zoster, gram-negative septicemia, neurologic symptoms, and deterioration of lupus nephritis. The second patient developed massive bronchopneumonia, necrotic cutaneous lesions, and progressive nephritis and died 2 weeks after completion of radiotherapy. These observations, although limited to two patients, indicate that total lymphoid irradiation in patients with severe systemic lupus erythematosus should be regarded as strictly experimental.
- Research Organization:
- Hadassah Univ. Hospital, Jerusalem, Israel
- OSTI ID:
- 5269201
- Journal Information:
- Ann. Intern. Med.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
LUPUS
RADIOTHERAPY
LYMPHATIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
SIDE EFFECTS
DEATH
IMMUNOSUPPRESSION
PATIENTS
PREDNISONE
ADRENAL HORMONES
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
CORTICOSTEROIDS
DISEASES
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
KETONES
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
PREGNANES
RADIATION EFFECTS
RADIOLOGY
SKIN DISEASES
STEROID HORMONES
STEROIDS
THERAPY
TUBERCULOSIS
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)