Tests for induction of presumed dominant-lethal effects in female mice

Conference · Tue Jan 01 00:00:00 EST 1985

OSTI ID:5267970

Generoso, W M; Cain, K T; Hughes, L A; Braden, P W

The two carcinogens, benzo(a)pyrene (BP), and 2-acetylaminofluorene (2AAF), and their respective noncarcinogenic analogs, pyrene (PYR) and 4-acetylaminofluorene (4AAF), were tested for induction of presumed dominant-lethal effects in female mice. Each chemical was administered as a single intraperitoneal injection using the maximum dose that could be given as limited either by toxicity or solubility. The study was conducted in at least two stocks of females and the induction of presumed dominant-lethal response was determined in oocytes in maturing follicles. Among the four compounds studied, only BP induced clear-cut presumed dominant-lethal effects. In addition, it had cytotoxic effects on the oocytes resulting in marked reduction in the reproductive performance of treated females. 11 refs., 1 fig., 4 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5267970
• Report Number(s): CONF-8505178-2; ON: DE85016961
• Resource Relation: Conference: Collaborative study on short-term tests for genotoxicity and carcinogenicity, Cap d'Adge, France, 14 May 1985
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLAMINOFLUORENES
GENETIC EFFECTS
BENZOPYRENE
PYRENE
CARCINOGENS
DOMINANT MUTATIONS
FEMALES
LETHAL MUTATIONS
MICE
OOGONIA
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
CONDENSED AROMATICS
GERM CELLS
HYDROCARBONS
MAMMALS
MUTATIONS
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)