Studies on radiosensitive lines of Drosophila. IX. Analysis of fertility and frequency of dominant lethal mutations in the gamma-irradiated females of the mutant line rad(2)201/sup G1/

Journal Article · Sat Mar 01 04:00:00 EST 1986 · Sov. Genet. (Engl. Transl.); (United States)

OSTI ID:5719626

Varentsova, E R; Sharygin, V I; Khromykh, Yu M

Fertility and frequency of dominant lethal mutations (DLM) induced by gamma rays in females at the age of 0-5 h and 5-7 days were studied in the radiosensitive mutant rad(2)201/sup G1/ of Drosophila. It has been found that the oocytes of mutant lines are more radiosensitive as compared to those of the wild type flies when compared on the basis of DLM frequency obtained through the entire maturation period. The early oocytes of stages 2-7, i.e., at the stages corresponding to the recombination-defective properties of mutation rad(2)201/sup g1/ are the most sensitive. It has also been demonstrated that the gamma-ray doses exceeding 10 Gy cause a strong sterilizing effect in the mutant females as a result of destruction and resorption of the egg chamber, irradiated at the stages of previtellogenic growth of oocytes. In the radiosensitive mutant females, the sensitivity of the oocytes for DLM induction does not correlate with the sensitivity of the ovarian follicles toward the resorbing effect of gamma rays. The possible involvement of the mutant locus in the genetic processes in different specialized cells of the sexual pathway in Drosophila is discussed.

• Research Organization: B. P. Konstantinov Leningrad Institute of Nuclear Physics, USSR
• OSTI ID: 5719626
• Journal Information: Sov. Genet. (Engl. Transl.); (United States), Journal Name: Sov. Genet. (Engl. Transl.); (United States) Vol. 21:9; ISSN SOGEB
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DIPTERA
DOMINANT MUTATIONS
DOSE-RESPONSE RELATIONSHIPS
DROSOPHILA
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FERTILITY
FLIES
FRUIT FLIES
GAMETES
GAMETOGENESIS
GAMMA RADIATION
GENE RECOMBINATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GERM CELLS
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
IRRADIATION
LETHAL MUTATIONS
MUTAGENESIS
MUTANTS
MUTATIONS
OOCYTES
OOGENESIS
OVA
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY