Modifications of circular DNA by photoalkylation
Conference
·
· Radiat. Res.; (United States)
OSTI ID:5265672
The effects of photoalkylation on superhelical PM2 DNA were examined. The chief product was 8-(2-hydroxy-2-propyl)guanine, formed exclusively in sequences of alternating purines and pyrimidines. Other purine damages included 8-(2-hydroxy-2-propyl)adenine and smaller quantities of two uncharacterized adenine products. DNA strand breaks were formed with increasing irradiation. A small quantity of thymine-containing photodimers was formed. Photoalkylation of poly(dG-dC):poly(dG-dC) reduced the concentration of salt required to effect inversion of the circular dichroic spectrum. This suggests that photoalkylation induces the transition of poly(dG-dC):poly(dg-dC) from the right-handed B form of DNA to the left-handed Z form.
- Research Organization:
- Temple Univ. School of Medicine, Philadelphia, PA
- OSTI ID:
- 5265672
- Report Number(s):
- CONF-860423-
- Conference Information:
- Journal Name: Radiat. Res.; (United States) Journal Volume: 103:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATION
AROMATICS
AZAARENES
BACTERIOPHAGES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBON 14 COMPOUNDS
CHEMICAL REACTIONS
DICHROISM
DNA
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MICROORGANISMS
NEAR ULTRAVIOLET RADIATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PHOTOCHEMICAL REACTIONS
PURINES
PYRIMIDINE DIMERS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
STRAND BREAKS
TRITIUM COMPOUNDS
ULTRAVIOLET RADIATION
VIRUSES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATION
AROMATICS
AZAARENES
BACTERIOPHAGES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBON 14 COMPOUNDS
CHEMICAL REACTIONS
DICHROISM
DNA
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MICROORGANISMS
NEAR ULTRAVIOLET RADIATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PHOTOCHEMICAL REACTIONS
PURINES
PYRIMIDINE DIMERS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
STRAND BREAKS
TRITIUM COMPOUNDS
ULTRAVIOLET RADIATION
VIRUSES