Extreme sensitivity of enveloped viruses, including herpes simplex, to long-chain unsaturated monoglycerides and alcohols

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Antimicrob. Agents Chemother.; (United States)

DOI:https://doi.org/10.1128/AAC.15.1.67· OSTI ID:5265143

Sands, J; Auperin, D; Snipes, W

Unsaturated monoglycerides and alcohols of chain lengths of 16 to 18 carbons were found to be extremely potent inactivators of two enveloped viruses, herpes simplex virus type 2 and bacteriophage phi 6. The lipid-containing bacteriophage PM2 was also inactivated by some of these amphiphilic molecules. Treatment of herpes simplex virus type 2 with these compounds at concentrations as low as 0.2 ..mu..M reduced virus survival to 50% in 30 min, making these agents the most potent inactivators of herpes simplex viruses discovered that are not cytotoxic to mammalian cells. Detailed characterizations of the effects of unsaturated monoglycerides and alcohols on bacteriophages phi 6 and PM2 showed that the inactivated phi 6 virion remained nearly intact but that PM2 was almost completely disrupted by the inactivating treatment. Some of the compounds inactivate the viruses even at low temperature (0/sup 0/C). Excess amounts of diglycerides and phospholipids interfere with the inactivating abilities of some of the unsaturated monoglycerides and alcohols against phi 6 and PM2. Our findings suggest that the unsaturated monoglycerides and some of the unsaturated alcohols should be further studied as potential antiviral agents. Particularly for application to herpesvirus-infected areas of the skin and accessible epithelium.

• Research Organization: Lehigh Univ., Bethlehem, PA
• OSTI ID: 5265143
• Journal Information: Antimicrob. Agents Chemother.; (United States), Journal Name: Antimicrob. Agents Chemother.; (United States) Vol. 15:1; ISSN AMACC
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALCOHOLS
BACTERIOPHAGES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACID ESTERS
CHEMOTHERAPY
DAYS LIVING RADIOISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EPITHELIUM
ESTERS
HERPES SIMPLEX
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MICROORGANISMS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASITES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
SKIN
SKIN DISEASES
SURVIVAL CURVES
THERAPY
TISSUES
TOXICITY
TRACER TECHNIQUES
VIRUSES