Inhibition of phorbol ester-induced tumor promotion in mice by vitamin A analog and anti-inflammatory steroid

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5260523

Weeks, C E ^[1]; Slaga, T J; Hennings, H; Gleason, G L; Bracken, W M

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1. Oak Ridge National Lab., TN

The effects of a vitamin A analog, TMMP ethyl retinoate (abbreviated Ro 10-9359), and an anti-inflammatory steroid, fluocinoione acetonide (abbreviated FA), given alone or together were studied in a two-stage carcinogenesis system. the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was used as the tumor promoter in a DMBA-initiated mouse skin system. Two stocks of female mice, which differ in their degrees of sensitivity to skin carcinogenesis, were used. A dose-dependent inhibition of carcinogenic expression, as determined by a decreased number of papillomas per animal, was observed in each mouse stock with the use of both FA and Ro 10-9359 were given alone. When FA and RO 10-9359 were given together, an enhanced effect on the lowering of tumor incidence was noted. FA effectively inhibited tumor formation in the sensitive mouse stock even when the steroid was given 1 day prior to TPA treatment under conditions of unusually high doses of initiator (DMBA) and/or promoter (TPA). These results suggest that both anti-inflammatory steroids and retinoids inhibit tumor promotion and can be effectively used as a combination regimen for increased chemopreventive response.

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5260523
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 63:2; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CARCINOGENESIS
CARCINOGENS
CAROTENOIDS
CHEMOTHERAPY
DISEASES
ESTERS
HYDROCARBONS
INFLAMMATION
INHIBITION
MAMMALS
MICE
ORGANIC COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
PHORBOL ESTERS
PIGMENTS
RODENTS
STEROIDS
SYNERGISM
TERPENES
THERAPY
TUMOR CELLS
VERTEBRATES
VITAMIN A
VITAMINS