Comparioson of the effects of neutron and/or photon irradiation on spontaneous squamous-cell carcinoma in mice
Journal Article
·
· Radiology; (United States)
OSTI ID:5246498
The effect of 30-MeV D/sup +/ ..-->.. Be NIRS cyclotron neutrons on a spontaneous NR-S1 squamous-cell carcinoma was studied. The TD/sub 50/ (number of tumor cells required for transplantation in half the sites) and tumor growth delay time (TGD) were determined. The RBE of 200-kVp x rays at the 10% survival level was 1.9 for aerobic cells and 2.0 for hypoxic cells; the OER at the same level was 1.7. Tumor cells irradiated with neutrons were unable to repair potentially lethal damage, in contrast to x-irradiated tumor cells. The RBE of 50-MeV D/sup +/ ..-->.. Be neutrons was inversely related to deuteron energy for hypoxic cells. The relationship between TGD and peak skin reaction indicated no benefit from mixed beams or 5 neutron doses.
- Research Organization:
- National Inst. of Radiological Sciences, Chiba, Japan
- OSTI ID:
- 5246498
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 134:1; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
FAST NEUTRONS
FERMIONS
GRAPHS
HADRONS
INFORMATION
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
NUMERICAL DATA
OXYGEN ENHANCEMENT RATIO
RADIATION EFFECTS
RADIATIONS
RBE
RODENTS
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
FAST NEUTRONS
FERMIONS
GRAPHS
HADRONS
INFORMATION
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
NEUTRONS
NUCLEONS
NUMERICAL DATA
OXYGEN ENHANCEMENT RATIO
RADIATION EFFECTS
RADIATIONS
RBE
RODENTS
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES
X RADIATION