Repair of potentially lethal radiation damage in acute and chronically hypoxic tumor cells in vivo

Journal Article · Sun Feb 01 04:00:00 EST 1976 · Radiology, v. 118, no. 2, pp. 447-451

OSTI ID:4117343

Urano, M; Nesumi, N; Ando, K; Koike, S; Ohnuma, N

The ability of animal tumor cells to repair potentially lethal damage was studied in vivo. Fifth-generation isotransplants of a spontaneous mouse squamous-cell carcinoma were irradiated under tourniquet-induced hypoxia or in air. Tumors were removed either immediately or 6 hours after irradiation and dose-response curves were determined by TD$sub 50$ assays. Repair was attributed to cells in the hypoxic cell component for animals irradiated in air. Extensive repair was also noted for those irradiated under hypoxic conditions. Implications of these results are discussed. (auth)

• Research Organization: National Inst. of Radiological Sciences, Chiba, Japan
• NSA Number: NSA-33-017449
• OSTI ID: 4117343
• Journal Information: Radiology, v. 118, no. 2, pp. 447-451, Journal Name: Radiology, v. 118, no. 2, pp. 447-451; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

*ANOXIA-- RADIOSENSITIVITY EFFECTS
*EXPERIMENTAL NEOPLASMS-- BIOLOGICAL RADIATION EFFECTS
*TUMOR CELLS-- BIOLOGICAL REPAIR
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
IN VIVO
LETHAL IRRADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
SURVIVAL TIME
X RADIATION