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Audiogenic seizures and cochlear damage in rats after perinatal antithyroid treatment

Journal Article · · Endocrinology; (United States)
;
The feeding of goitrogens during pregnancy and lactation causes the offspring of rats to be partially deaf and persistently sensitive to audiogenic seizures. The most potent goitrogen, propylthiouracil, caused severe dysfunction and disorganization of the organ of Corti. Adult seizure-susceptible rats showed increased sensitivity to audiogenic seizures when they were fed propylthiouracil.
Research Organization:
Univ. of Tennessee Center for the Health Sciences, Memphis
DOE Contract Number:
AS05-76EV01643
OSTI ID:
5245199
Journal Information:
Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 106:6; ISSN ENDOA
Country of Publication:
United States
Language:
English

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Related Subjects

550100 -- Behavioral Biology
550900 -- Pathology
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTITHYROID DRUGS
AUDITORY ORGANS
BIOLOGICAL EFFECTS
BODY
DISEASES
DRUGS
FETUSES
LACTATION
MAMMALS
NEONATES
NERVOUS SYSTEM
ORGANS
PATHOLOGICAL CHANGES
RATS
RODENTS
SENSE ORGANS
SENSITIVITY
SOUND WAVES
VERTEBRATES