Cerebral blood flow studies in man using recirculation corrected height/area (H/A) computations for intravenous injection of 133Xenon
Our height/area (recirculation-corrected) non-invasive cerebral blood flow method compares well with k1 values and k average as determined from k1, k2, p1 and p2 by Obrist computations. The height/area method provides regional flow measurements with less variability than k1 due to low regional head counts, head motion and end-tidal gas sample variations. Derivation of the mathematical model is for a single flow compartment and suited for tomographic measurements such as PET. Collimated detector data using our computation provides a good approximation of flow even for multiple compartments. Our approach permits a lower counting rate by either a smaller isotope dose or better detector collimation than multicompartment curve fitting methods.
- Research Organization:
- University of Miami School of Medicine, Department of Neurology, Florida
- OSTI ID:
- 5244634
- Journal Information:
- Stroke; (United States), Vol. 13:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Noninvasive method of estimating human newborn regional cerebral blood flow
Simultaneous estimations of blood brain barrier (BBB) permeability and local cerebral blood volume (CBV) in human brain tumors with positron tomography and Ga-68 EDTA
Related Subjects
BLOOD FLOW
CALCULATION METHODS
MATHEMATICAL MODELS
CEREBRUM
POSITRON COMPUTED TOMOGRAPHY
DISEASES
DIAGNOSIS
XENON 133
COMPARTMENTS
INTRAVENOUS INJECTION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
TOMOGRAPHY
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics