Improved method for noninvasive measurement of regional cerebral blood flow by /sup 133/Xe inhalation. I. description of method and normal values obtained in healthy volunteers

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Stroke; (United States)

OSTI ID:6620607

Meyer, J S; Ishihara, N; Deshmukh, V D; Naritomi, H; Sakai, F; Hsu, M C; Pollack, P

A clinical method for noninvasive measurement of regional cerebral blood flow (rCBF) and blood volume (rCBV) is described, based on Obrist's 10 minute, desaturation method after 1 minute inhalation of /sup 133/Xe. Sixteen collimated probes are placed over both hemispheres and brain stem-cerebellar regions. End-tidal /sup 133/Xe curves are used for correction of recirculation. KEV discriminators are set to record gamma and x-ray activity separately. Values are printed out automatically by a computer on a brain map. Extracerebral contamination is reduced by (1) computing curves from gamma activity, (2) applying pressure on the scalp beneath the probes, (3) 1 minute inhalation of /sup 133/Xe and recording desaturation curves for 10 minutes, thereby minimizing slow clearance from extracranial tissues. Normal values for both fast and slow compartments are reproducible and are in good agreement with the carotid injection method. The speech dominant hemisphere has higher flow than the right under conditions described. Posterior portions of the cranium over the cerebellum and brain stem appear to have higher flow gray values than the cerebral cortex. Gray matter flow decreases with advancing age.

• Research Organization: Vetrans Administration Hospital, Houston, TX
• OSTI ID: 6620607
• Journal Information: Stroke; (United States), Journal Name: Stroke; (United States) Vol. 9:3; ISSN SJCCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADULTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD CIRCULATION
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
ELECTROMAGNETIC RADIATION
EVEN-ODD NUCLEI
GAMMA RADIATION
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEASURING METHODS
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIATIONS
RADIOISOTOPES
USES
X RADIATION
XENON 133
XENON ISOTOPES