Protective effects of interferon in mice previously exposed to lethal irradiation
Journal Article
·
· Radiat. Res.; (United States)
The radioprotective action of interferon (IF) in increasing the survival time of mice lethally irradiated 24 h previously was evaluated. A single intraperitoneal injection of 30,000 units of IF administered 1 day following a LD/sub 100/ dose of irradiation significantly prolonged the mean survival time of the animals. Multiple inoculations of IF given 1,3, and 5 days after irradiation only slightly increased the survival time over that observed in mice receiving single injections. Marked decreases in total number of splenocytes were observed in irradiated mice as well as in the mice receiving postirradiation IF therapy, whereas total peripheral white blood cell counts were not appreciably changed when evaluated 3 days after X irradiation. Natural lymphocyte killer activity of splenocytes from irradiated animals receiving IF was significantly increased, suggesting that the protective action of IF could be partially attributable to the boosting of some depressed immune functions.
- Research Organization:
- National Cancer Inst., Bethesda, MD
- OSTI ID:
- 5244268
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 81:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
IMMUNITY
INFORMATION
INJECTION
INTAKE
INTERFERON
INTRAPERITONEAL INJECTION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LETHAL IRRADIATION
MAMMALS
MICE
NUMERICAL DATA
POST-IRRADIATION THERAPY
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL TIME
THERAPY
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
IMMUNITY
INFORMATION
INJECTION
INTAKE
INTERFERON
INTRAPERITONEAL INJECTION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LETHAL IRRADIATION
MAMMALS
MICE
NUMERICAL DATA
POST-IRRADIATION THERAPY
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL TIME
THERAPY
VERTEBRATES
X RADIATION