Role of toxicological interactions in chemical carcinogenesis

Conference · Sat Dec 31 23:00:00 EST 1983 · Toxicol. Pathol.; (United States)

OSTI ID:5241557

Witschi, H

Toxicological interactions may occur not only when exposure to two or more chemicals is simultaneous, but also when exposures are separated in time. Often the sequence of exposure determines the nature of the toxicological response. This is illustrated with the two hindered phenolic antioxidants, butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA). Evidence available suggests that in certain tissues exposure to BHT first and then to a carcinogen is without significant consequences, whereas exposure to BHT after a carcinogen may enhance tumor formation. On the other hand, exposure to BHA before carcinogen administration often has a protective effect, whereas exposure to BHA after a carcinogen sometimes protects and sometimes is without any influence. Mechanisms underlying these interactions may be induction of mixed function oxidase, production of cell hyperplasia or other, as yet ill-defined, events such as modification of biological reactivity. 15 references, 5 figures, 1 table.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5241557
• Journal Information: Toxicol. Pathol.; (United States), Journal Name: Toxicol. Pathol.; (United States) Vol. 12:1; ISSN TOPAD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIOXIDANTS
AROMATICS
BIOLOGICAL PATHWAYS
BODY
CARCINOGENESIS
CARCINOGENS
DATA
DISPERSIONS
ENZYMES
EXPERIMENTAL DATA
HYDROXY COMPOUNDS
INFORMATION
LUNGS
MAMMALS
METABOLIC ACTIVATION
MICE
MIXED-FUNCTION OXIDASES
MIXTURES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PATHOGENESIS
PHENOLS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES