Radiosensitization of Drosophila sperm by commonly used food additives. Butylated hydroxyanisole and butylated hydroxytoluene

Journal Article · Mon Dec 31 23:00:00 EST 1973 · Int. J. Radiat. Biol., v. 25, no. 1, pp. 67-72

DOI:https://doi.org/10.1080/09553007414550071· OSTI ID:4331428

Prasad, O; Kamra, O P

The radiosensitivity of sperm of Drosophila melanogaster was enhanced by a factor of about two by commonly used food additives. Neither butylated hydroxyanisole (BHA) nor butylated hydroxytoluene (BHT), with and without gamma irradiation (0, At the concentration used (0.001% BHA; 0.001% BHT), the two phenolic antioxidants seem to induce X/sup BETA /-chromosome loss in the sperm (XO males in F/sub 1/) and sex-linked recessive lethal mutations in F/sub 2/, although these effects were not statistically significant. However, both agents proved to be potent radiosensitizers for the sex-linked recessive lethals. (auth)

• Research Organization: Dalhousie Univ., Halifax, Nova Scotia
• NSA Number: NSA-29-029835
• OSTI ID: 4331428
• Journal Information: Int. J. Radiat. Biol., v. 25, no. 1, pp. 67-72, Journal Name: Int. J. Radiat. Biol., v. 25, no. 1, pp. 67-72; ISSN IJRBA
• Country of Publication: United Kingdom
• Language: English

Related Subjects

*ANTIOXIDANTS-- RADIOSENSITIVITY EFFECTS
*DROSOPHILA-- RADIOSENSITIVITY
*RADIOSENSITIZERS-- ANTIOXIDANTS
*SPERMATOZOA-- RADIOSENSITIVITY
ADDITIVES
BIOLOGICAL RADIATION EFFECTS
CRESOLS
DILUTION
DOSE-RESPONSE RELATIONSHIPS
FOOD
GAMMA RADIATION
LETHAL MUTATIONS
N48531* --Life Sciences--Radiation Effects on Animals-- Invertebrates--Basic Studies
SEX RATIO