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Studies on radiosensitization of Escherichia coli cells by cis-platinum complexes

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5237069
; ;
We recently reported that the antitumor drug cis-Pt(NH/sub 3/)/sub 2/Cl/sub 2/ (cis-DDP) produces significant radiosensitization of anoxic E coli C cells. We have extended these studies to three other platinum drugs, all of which have been shown to be more effective antitumor drugs than cis-DDP. The drugs are: cis-dichloro bis(ethylene imine) Pt(II) (cis-DEP); cis-dichlorobicyclopentylamine Pt(II) (cis-PAD); and Pt-thymine blue (cis-PTB). Survival curve studies indicate that these drugs all produce greater anoxic radiosensitization of E coli C than cis-DDP at concentrations which are less toxic to the cells than similar concentrations of cis-DDP. If the cells are treated with any one of these drugs for two hours and then washed to remove the drug before irradiation, no detectable radiosensitization is found. We conclude that these drugs have the potential for being useful agents in combined modality therapy and that they warrant further study in mammalian systems.
Research Organization:
Univ. of Kansas, Lawrence
OSTI ID:
5237069
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOXIA
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
COMPLEXES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
EXPERIMENTAL DATA
GAMMA RADIATION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PLATINUM COMPLEXES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SURVIVAL CURVES
THERAPY
TOXICITY
TRANSITION ELEMENT COMPLEXES
YEARS LIVING RADIOISOTOPES