Search for suppression of T cells specific for the second nonhost H-2 haplotype in F/sub 1/. -->. P irradiation bone marrow chimeras
Irradiation bone marrow chimeras were made by lethally irradiating parental (P) mice and reconstituting them with T cell-depleted bone marrow cells from F/sub 1/ hybrid offsprings. These F/sub 1/ ..-->.. P chimeric lymphocytes were then analyzed for suppressor mechanisms that could cause the differentiation of effector T cells whose responsiveness was restricted in specificity to the host parent's H-2 haplotype. No evidence was detected for acute or chronic suppression of the second parent's restriction specificity in tests of cytotoxic T cell activity against virus-infected targets. Therefore, F/sub 1/ ..-->.. P irradiation bone marrow chimeras as tested here do not contain mechanisms that suppress the restriction specificity of the second parent, which is not a host to the maturing F/sub 1/T cells, at least at the effector stage or during differentiation.
- Research Organization:
- Scripps Clinic and Research Foundation, La Jolla, CA
- OSTI ID:
- 5236167
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 122:5; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
IMMUNE REACTIONS
INHIBITION
MAMMALS
MICE
MICROORGANISMS
MOSAICISM
PARASITES
PROGENY
RADIATION CHIMERAS
RODENTS
SOMATIC CELLS
SPECIFICITY
SPLEEN CELLS
THYMOCYTES
VERTEBRATES
VIRUSES