Multinuclear NMR studies of naturally occurring nuclei

Journal Article · Tue Jan 31 23:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:5217130

Burt, C T ^[1]; Koutcher, J A

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1. Massachusetts General Hospital, Boston

The ability to obtain nuclear magnetic resonance spectra from spatially localized regions of living animals and patients has led to the possibility of measuring biochemical processes in vivo. Localization is generally achieved through the use of surface coils. Using this technique, intracellular pH, and concentrations of high-energy phosphates and ''abnormal'' marker compounds have been measured in animal organs (both in vitro and in vivo) and in human brain and muscle (in vivo). The majority of studies have used the P-31 nucleus, but carbon (C-13) and hydrogen (H-1) have also been studied. However, both C-13 and H-1 experiments have technical difficulties. Carbon-13 has a low natural abundance, and H-1-containing metabolites may have their signals obscured by the large water peak. The phosphorus studies have been largely preclinical, but diagnostic possibilities are appearing from the many research problems now under investigation.

• OSTI ID: 5217130
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
BRAIN
CARBON 13
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
DISEASES
DOCUMENT TYPES
EVEN-ODD NUCLEI
HYDROGEN 1
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
MUSCLES
NEONATES
NEOPLASMS
NERVOUS SYSTEM
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHOSPHORUS 31
PHOSPHORUS ISOTOPES
RABBITS
RATS
RELAXATION TIME
RESOLUTION
RESONANCE
REVIEWS
RODENTS
SPATIAL RESOLUTION
SPECTRA
STABLE ISOTOPES
VERTEBRATES